Abstract
Alteration in lymphocyte trafficking and prevention of graft rejection in rodents observed on exposure to FTY720 (1) or its corresponding phosphate ester 2 can be induced by the systemic administration of potent sphingosine-1-phosphate receptor agonists exemplified by 19. The similar S1P receptor profiles of 2 and 19 coupled with their comparable potency in vivo supports a connection between S1P receptor agonism and immunosuppressive efficacy.
MeSH terms
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Animals
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CHO Cells
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Cricetinae
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Fingolimod Hydrochloride
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Humans
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Immunologic Factors / administration & dosage*
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Immunologic Factors / chemistry*
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Immunologic Factors / metabolism
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / chemistry
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Immunosuppressive Agents / metabolism
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Injections, Intravenous
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Male
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Mice
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Propylene Glycols / administration & dosage*
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Propylene Glycols / chemistry*
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Propylene Glycols / metabolism
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Rats
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Rats, Sprague-Dawley
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Receptors, Lysosphingolipid / agonists*
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Receptors, Lysosphingolipid / metabolism
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Sphingosine / analogs & derivatives
Substances
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Immunologic Factors
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Immunosuppressive Agents
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Propylene Glycols
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Receptors, Lysosphingolipid
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Fingolimod Hydrochloride
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Sphingosine